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Updated: Jun 23, 2026

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
Impact of prolonged treatment with linezolid on the human gut flora
Diamantis P Kofteridis1, Polychronis Malliotakis, Sofia Maraki
1Department of Internal Medicine, University Hospital of Heraklion, PO Box 1352, 71110 Heraklion, Crete, Greece. kofterid@med.uoc.gr
Abstract:
A 79-year-old male was treated for 6 months with linezolid for prosthetic knee joint osteomyelitis. At the end of this 6-month period, quantitative stool cultures revealed partial loss of the normal gut flora and concomitant colonization by opportunistic pathogens such as Pseudomonas aeruginosa and other Gram-negatives. Follow-up cultures at 6 weeks after antibiotic discontinuation revealed restoration of the normal flora. Prolonged linezolid administration may lead to replacement of normal gut flora by pathogenic microorganisms, which under certain conditions might cause systemic infections.
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