Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Canine meningitis and meningoencephalitis in eastern Australia.

Australian veterinary journal·2025

Same author

Lumbar nerve root compression resulting from extrusion of intervertebral disc material after prophylactic disc fenestration.

Australian veterinary journal·2025

Same author

Reply to: Concerns regarding proposed groundwater Earth system boundary.

Nature·2024

Same author

The Impact of Hearing Aids on Listening Effort and Listening-Related Fatigue - Investigations in a Virtual Realistic Listening Environment.

Trends in hearing·2024

Same author

Pandemic lockdowns: who feels coerced and why? - a study on perceived coercion, perceived pressures and procedural justice during the UK COVID-19 lockdowns.

BMC public health·2024

Same author

Operational changes to the lupus intervention fatigue trial as a result of COVID-19: An update to the study protocol.

Contemporary clinical trials communications·2023

Search research articles

Related Experiment Videos

Lupus and cancer.

M Gayed¹, S Bernatsky, R Ramsey-Goldman

¹Rheumatology Research Group, School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham, UK.

|April 28, 2009

Summary

This summary is machine-generated.

Systemic lupus erythematosus (SLE) patients face higher risks of certain cancers, including non-Hodgkin lymphoma and lung cancer. Increased lupus disease activity and immunosuppressant use may contribute to these risks, necessitating vigilant monitoring and screening.

Related Experiment Videos

Area of Science:

Oncology
Rheumatology
Immunology

Background:

Systemic lupus erythematosus (SLE) is associated with an elevated risk of specific malignancies.
Hematologic malignancies, particularly non-Hodgkin lymphoma, show a 3-4 fold increased incidence in SLE patients compared to the general population.
Other cancers, including lung cancer and cervical dysplasia, are also more prevalent in individuals with SLE.

Purpose of the Study:

To investigate the increased cancer susceptibility in patients diagnosed with systemic lupus erythematosus (SLE).
To identify potential contributing factors to the elevated cancer risk in SLE patients, including disease activity and iatrogenic exposures.
To highlight the importance of routine screening for specific cancers in the SLE population.

Main Methods:

This study is a review of existing literature and epidemiological data.
Analysis of cancer incidence rates in SLE patients versus the general population.
Exploration of the correlation between SLE disease activity, immunosuppressive therapy, and cancer development.

Main Results:

SLE patients exhibit a significantly higher risk for non-Hodgkin lymphoma, lung cancer, and cervical dysplasia.
Immunosuppressive drug exposure and high lupus disease activity are implicated as potential drivers of cancer risk.
Smoking is identified as a major contributor to the increased lung cancer risk in SLE patients.

Conclusions:

Systemic lupus erythematosus confers an increased risk for specific hematologic and non-hematologic malignancies.
Management strategies for SLE should incorporate awareness and mitigation of cancer risks.
Regular screening for cancers such as non-Hodgkin lymphoma and cervical dysplasia is crucial for early detection and improved outcomes in SLE patients.