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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Articles linked to this work by shared authors, journal, and citation graph.

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Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
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Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

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Identifying Predictors of Weight-Related Outcomes With Fixed-Dose, Extended-Release Naltrexone and Bupropion Among Treatment-Adherent Patients in Phase 3 COR Trials: A Treatment Target Analysis.

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Treating Obesity With Pharmacotherapy: Making Sense of the Evolving Science When Data Are Vast but Direct Comparative Evidence Is Sparse.

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Erratum: Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society.

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Corrigendum to "Nutritional priorities to support GLP-1 therapy for obesity: A joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society [Obesity Pillars 15 (2025) 100181].

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Related Experiment Video

Updated: Jun 23, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Expert panel on weight loss surgery: executive report update.

George L Blackburn1, Matthew M Hutter, Alan M Harvey

  • 1Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. gblackbu@bidmc.harvard.edu

Obesity (Silver Spring, Md.)
|April 28, 2009
PubMed
Summary

Updated guidelines for weight loss surgery (WLS) ensure patient safety amidst rapid changes. Evidence-based WLS improves health, reduces disease risk, and offers survival benefits, requiring multidisciplinary care and accredited centers.

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Area of Science:

  • Bariatric Surgery
  • Surgical Outcomes
  • Healthcare Policy

Background:

  • Weight loss surgery (WLS) techniques and patient demographics are rapidly evolving.
  • Previous evidence-based guidelines for WLS were published in 2004.
  • A vulnerable patient population requires specialized resources and multidisciplinary care for WLS.

Purpose of the Study:

  • To update existing evidence-based guidelines for weight loss surgery (WLS).
  • To ensure patient safety in the rapidly changing field of WLS.
  • To address new challenges and optimize treatment strategies in WLS.

Main Methods:

  • Comprehensive review of the most current scientific literature on WLS.
  • Development of evidence-based guidelines from peer-reviewed scientific publications.
  • Collaboration of over 100 specialists from diverse disciplines involved in WLS.

Main Results:

  • Weight loss surgery (WLS) reduces chronic disease risk factors, improves health, and confers a survival benefit.
  • Laparoscopic approaches have largely replaced open surgery for WLS.
  • Accreditation of WLS centers is required for reimbursement by government agencies and insurers.
  • Optimal WLS care necessitates multidisciplinary team collaboration and facility adaptations for severely obese patients.

Conclusions:

  • Updated guidelines are crucial for patient safety in WLS.
  • Evidence supports WLS benefits, including improved health and survival.
  • Standardized, multidisciplinary care at accredited centers is essential for effective WLS.
  • These updated standards will influence healthcare policy and WLS practices.