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Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Diabetic Ketoacidosis l: Introduction01:25

Diabetic Ketoacidosis l: Introduction

DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic ketone production, and...
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
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Related Experiment Video

Updated: Jun 23, 2026

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
10:41

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Published on: September 13, 2022

Clinical perspectives on lacosamide.

Jonathan J Halford1, Marc Lapointe

  • 1Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. halfordj@musc.edu

Epilepsy Currents
|April 28, 2009
PubMed
Summary
This summary is machine-generated.

Lacosamide, a new antiepileptic drug (AED), offers a novel dual mechanism for treating partial-onset seizures. Clinical trials suggest favorable efficacy and safety profiles compared to existing second-generation AEDs.

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Last Updated: Jun 23, 2026

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
10:41

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Published on: September 13, 2022

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Uncontrolled partial-onset seizures present a clinical challenge despite recent antiepileptic drug (AED) advancements.
  • Newer AEDs offer improved safety and novel mechanisms compared to older generations.

Purpose of the Study:

  • To review Lacosamide (LCM) for adjunctive treatment of partial-onset seizures.
  • Summarize preliminary Phase II and III trial data for LCM.
  • Compare LCM efficacy with other second-generation AEDs.

Main Methods:

  • Review of Phase II and III clinical trial data for Lacosamide.
  • Comparative analysis of efficacy data against other second-generation AEDs.

Main Results:

  • Lacosamide (LCM) demonstrates novel dual mechanisms of action.
  • Preliminary trial data indicate favorable pharmacokinetic and safety profiles for LCM.
  • Efficacy data suggests LCM is a promising option for partial-onset seizures.

Conclusions:

  • Lacosamide (LCM) represents a significant advancement in managing uncontrolled partial-onset seizures.
  • Its unique mechanisms and favorable profile warrant consideration in clinical practice.
  • LCM offers a valuable alternative to existing second-generation AEDs.