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Updated: Jun 23, 2026
03:40
Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
[Hematopoietic stem cell transplantation. Indications, foundations and perspective]
1Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation, Medizinische Hochschule Hannover, Hannover.
Der Internist
|April 28, 2009
Summary
Hematopoietic stem cell transplantation (HSCT) is a vital therapy for bone marrow and immune disorders. Allogeneic HSCT significantly improves survival rates for acute leukemias, with expanded eligibility for older patients.
Area of Science:
- Hematology
- Immunology
- Oncology
Context:
- Hematopoietic stem cell transplantation (HSCT) is a cornerstone therapy for various hematologic, oncologic, and immunologic conditions.
- Autologous HSCT is crucial for multiple myeloma and lymphoma relapse, while allogeneic HSCT is primary for acute leukemias.
Purpose:
- To review the current applications and advancements in hematopoietic stem cell transplantation.
- To highlight the selection criteria and prognostic factors influencing allogeneic HSCT outcomes in acute leukemias.
- To discuss the expanded eligibility and considerations for elderly patients undergoing HSCT.
Summary:
- Allogeneic HSCT offers a survival improvement from 0-20% to 30-60% in acute leukemias, particularly when risk factors for chemotherapy resistance are identified.
- Advanced conditioning protocols have extended the upper age limit for HSCT to 70 years, emphasizing the importance of comorbidity assessment in older adults.
- The growing population of long-term HSCT survivors necessitates a thorough understanding of potential late toxicities, including secondary malignancies.
Impact:
- Enhanced survival rates and expanded therapeutic options for patients with severe hematologic and immune system disorders.
- Improved patient selection strategies and risk stratification for allogeneic HSCT, optimizing treatment efficacy.
- Increased focus on long-term follow-up and management of late adverse effects in HSCT survivors.
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