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Updated: Jun 23, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Intestinal loop lengthening: early treatment of vanishing bowel
A Buluggiu1, M Haddad, M Coste
1Department of Pediatric Surgery, Hôpital Timone Enfant, 264, Rue Saint-Pierre, 13385, Marseille Cedex 05, France.
Insights
Early gut lengthening offers a promising treatment for infants with short bowel syndrome resulting from gastroschisis. This intervention addresses complex intestinal malformations, improving outcomes for affected children.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Neonatal Care
Background:
- Short bowel syndrome (SBS) is a severe condition often requiring surgical intervention.
- Bianchi's procedure is a recognized treatment for SBS in children, typically performed after infancy.
- Gastroschisis can lead to complex gastrointestinal issues, including vanishing gut and intestinal atresia.
Observation:
- This case involves a neonate with gastroschisis experiencing prenatal spontaneous closure of the abdominal defect.
- The infant presented with a 'vanishing gut,' leading to intestinal atresia, absence of the ileocecal valve, and dilated residual intestines.
- Traditional surgical approaches for SBS may not be suitable for such complex presentations.
Findings:
- The authors propose and detail the successful application of early intestinal lengthening procedure (ILP) in this challenging case.
- This early intervention aimed to address the malrotation and malabsorption associated with the shortened and malformed intestine.
- The procedure was performed earlier than the typical age for Bianchi's procedure.
Implications:
- Early gut lengthening (ILP) may represent a viable alternative or adjunct to established SBS treatments in complex neonatal surgical cases.
- This approach could potentially improve long-term outcomes for children with severe intestinal failure due to gastroschisis.
- Further research is warranted to evaluate the efficacy and long-term benefits of early ILP in similar pediatric populations.
Abstract:
Bianchi's procedure experience for short bowel syndrome in children is positive. This technique is generally performed after the first year of life. Here the authors propose a case of gastroschisis with prenatal spontaneous closure of abdominal defect and vanishing gut presenting as intestinal atresia, absence of ileo-cecal valve, and residual short intestinal dilatation, treated by early gut lengthening (ILP).
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