Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a new operative 3D printed template-cranioplasty-concept for performing craniotomy in the posterior cranial fossa and validation of the system using a 3D printed simulation model: a preclinical feasibility study.

3D printing in medicine·2026
Same author

Noninvasive 3D-head-scan used for 3D-printed customized helm by patient undergoing decompressive hemicraniectomy.

Frontiers in bioengineering and biotechnology·2025
Same author

3D-printed skull model for enhancing training in external ventricular drainage within medical education.

3D printing in medicine·2025
Same author

Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections.

Cell host & microbe·2025
Same author

Effects of an extended MRI approval of an implantable spinal cord stimulation device on compliance with manufacturer's recommendations.

Pain practice : the official journal of World Institute of Pain·2025
Same author

IMAGINER 2-improving accuracy with augmented realIty navigation system during placement of external ventricular drains over Kaufman's, Keen's, Kocher's and Frazier's point.

Frontiers in surgery·2025

Related Experiment Video

Updated: Jun 23, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
06:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

A multiplexed approach to hit finding.

Mark Slack1, Dirk Winkler, Joachim Krämer

  • 1Evotec AG, Hamburg, Germany.

Current Opinion in Drug Discovery & Development
|April 28, 2009
PubMed
Summary
This summary is machine-generated.

Multiplex screening technologies provide rich data for drug discovery. Enhanced information density aids in selecting drug candidates, but requires deeper biological understanding for full potential.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Related Experiment Videos

Last Updated: Jun 23, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
06:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Area of Science:

  • Drug discovery and development
  • Biophysical and biochemical assays
  • Cellular assay technologies

Background:

  • Assay formats can yield multiple readouts per measurement, offering rich information.
  • High-content assays represent advanced small-molecule screening paradigms.
  • Drug discovery involves complex lead generation and optimization processes.

Purpose of the Study:

  • To highlight the benefits of information-rich multiplex screening technologies in drug discovery.
  • To discuss the role of enhanced information density in hit selection and optimization.
  • To explore the conditions under which multiplexed screening technologies can achieve their full potential.

Main Methods:

  • Review of assay formats, including biophysical, biochemical, and cellular assays.
  • Discussion of high-content screening as an advanced paradigm.
  • Analysis of information density in multiplex screening.

Main Results:

  • Multiplex screening technologies offer enhanced information density.
  • This enhanced information is beneficial for informed hit selection in drug discovery.
  • Emerging evidence supports the enhancement of hit and lead selection.

Conclusions:

  • Multiplex screening technologies are valuable for drug discovery due to their information-rich nature.
  • Realizing the full promise of these technologies depends on advancing our understanding of target pharmacology and biological systems.
  • Further research is needed to solidify the evidence for improved hit and lead selection.