Related Experiment Videos
Incidence of the mucopolysaccharidoses in Taiwan, 1984-2004
Hsiang-Yu Lin1, Shuan-Pei Lin, Chih-Kuang Chuang
1Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Abstract:
Previous studies on the incidence of the various types of mucopolysaccharidoses (MPS) in different populations have shown considerable variation. However, information regarding the incidence of MPS in the Asian population is lacking. An epidemiological study of the MPS disorders in Taiwan using multiple ascertainment sources was undertaken, and incidences of different types of MPS during the period of 1984-2004 were estimated. We compared our data with previous reports in different populations. The combined birth incidence for all MPS cases was 2.04 per 100,000 live births. MPS II (Hunter syndrome) had the highest calculated birth incidence of 1.07 per 100,000 live births (2.05 per 100,000 male live births), comprising 52% of all MPS cases diagnosed. The birth incidences of MPS I (Hurler syndrome), III (Sanfilippo syndrome), IV (Morquio syndrome), and VI (Maroteaux-Lamy syndrome) were 0.11, 0.39, 0.33, and 0.14 per 100,000 live births, respectively, which accounted for 6%, 19%, 16%, and 7% of all MPS, respectively. No cases of MPS III D (Sanfilippo syndrome type D), MPS IV B (Morquio syndrome type B), MPS VII (Sly syndrome) or MPS IX were ascertained during the study period. Overall incidence of MPS in Taiwan was consistent with that reported in Western populations. However, in contrast to the higher incidence of MPS I in most Western populations, this study showed a higher incidence of MPS II in Taiwan. It remains to be investigated whether this discrepancy is attributed to the under-diagnosis of MPS I in Taiwan or to ethnic differences.
Insights
This study estimated mucopolysaccharidoses (MPS) incidence in Taiwan, finding MPS II (Hunter syndrome) most common. Overall MPS rates align with Western data, but MPS II is higher than MPS I, unlike in Western populations.
Area of Science:
- Medical Genetics
- Epidemiology
- Rare Diseases
Background:
- Mucopolysaccharidoses (MPS) are rare genetic disorders with varying incidence globally.
- Data on MPS prevalence in Asian populations, particularly Taiwan, is limited.
- Understanding regional incidence is crucial for public health planning and resource allocation.
Purpose of the Study:
- To determine the incidence of various mucopolysaccharidoses (MPS) types in Taiwan.
- To compare the epidemiological data of MPS in Taiwan with previously reported global findings.
- To investigate potential ethnic or diagnostic differences influencing MPS prevalence.
Main Methods:
- An epidemiological study conducted in Taiwan from 1984 to 2004.
- Utilized multiple sources for case ascertainment to ensure comprehensive data collection.
- Calculated birth incidences for different MPS types and overall MPS prevalence.
Main Results:
- The combined birth incidence of all MPS cases in Taiwan was 2.04 per 100,000 live births.
- MPS II (Hunter syndrome) was the most prevalent type, accounting for 52% of cases (1.07 per 100,000 live births).
- Incidences of MPS I, III, IV, and VI were 0.11, 0.39, 0.33, and 0.14 per 100,000 live births, respectively.
Conclusions:
- The overall incidence of MPS in Taiwan is comparable to Western populations.
- Taiwan exhibits a higher incidence of MPS II (Hunter syndrome) compared to MPS I (Hurler syndrome), contrasting with most Western population studies.
- Further research is needed to determine if this discrepancy is due to under-diagnosis of MPS I or reflects genuine ethnic variations.