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Updated: Jun 23, 2026

14:57
Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
Rational design of an organometallic glutathione transferase inhibitor
Wee Han Ang1, Lorien J Parker, Anastasia De Luca
1Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Angewandte Chemie (International Ed. in English)
|April 28, 2009
Abstract:
Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.
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