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Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
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Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
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Chronic Pancreatitis II: Pathophysiology01:21

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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Cirrhosis I: Introduction01:23

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Related Experiment Video

Updated: Jun 23, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Cholestasis and cholestatic syndromes.

Gideon M Hirschfield1, Elizabeth J Heathcote

  • 1Liver Centre, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, Canada. gideon.hirschfield@uhn.on.ca

Current Opinion in Gastroenterology
|April 28, 2009
PubMed
Summary

Recent advances in cholestatic liver injury research offer new directions for treatment. Understanding cholangiocyte cell biology and clinical disease descriptions may lead to novel therapeutic approaches for conditions like primary biliary cirrhosis.

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Related Experiment Videos

Last Updated: Jun 23, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Creation of Reversible Cholestatic Rat Model
09:39

Creation of Reversible Cholestatic Rat Model

Published on: May 21, 2011

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

Area of Science:

  • Hepatology
  • Gastroenterology
  • Cell Biology

Background:

  • Cholestatic liver injury presents diverse etiologies, including toxins, genetic factors, and autoimmune conditions.
  • The clinical field of cholestasis is rapidly expanding with new research findings.

Purpose of the Study:

  • To review recent advancements in understanding cholestatic liver injury.
  • To highlight emerging research directions in both laboratory and clinical settings.

Main Methods:

  • Review of current literature on cholestatic liver injury.
  • Integration of findings from cell biology, genetics, and clinical studies.

Main Results:

  • Cell biology studies reveal insights into intracellular signaling molecules.
  • Genetic research identifies key roles for biliary transporters.
  • Clinical studies provide predictors of outcomes in cholestatic liver diseases.

Conclusions:

  • Current treatments for cholestasis are often nonspecific and lack efficacy.
  • Enhanced understanding of cholangiocyte biology and diseases like primary biliary cirrhosis and sclerosing cholangitis is paving the way for new therapeutic strategies.