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Updated: Jun 23, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55-70 years
Clare F Hodkinson1, Ellen E A Simpson, John H Beattie
1Northern Ireland Centre for Food and Health (NICHE) School of Psychology, University of Ulster, Coleraine, Northern Ireland.
Abstract:
A reciprocal relationship between the endocrine and immune system has been demonstrated under pathophysiological conditions. However, few studies have assessed the relationship between thyroid hormones and immune function in apparently healthy individuals. Therefore, to clarify our understanding of normal physiological endocrine-immune interactions this study aimed to examine the interrelationships between thyroid hormones and immunity in healthy individuals. Total triiodothyronine (T(3)), total thyroxine (T(4)) and markers of immune status were assessed in 93 free-living and apparently healthy individuals aged 55-70 years. T(3) and T(4) concentrations were determined by commercially available kits. Immune status was assessed using flow cytometry and biochemical markers. Statistical analysis was performed by partial correlation, controlling for age. Thyroid hormone concentration was positively associated with markers of inflammation (P
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