Related Experiment Video
Updated: Jun 23, 2026
08:22
In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Autophagy in ischemic preconditioning and hibernating myocardium
Lin Yan1, Junichi Sadoshima, Dorothy E Vatner
1Cardiovascular Research Institute, Department of Cell Biology & Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
Autophagy
|April 29, 2009
Summary
Autophagy plays a key role in cardioprotection from repetitive ischemia, but its involvement in traditional ischemic preconditioning is less significant. This study investigates autophagy
Area of Science:
- Cardiovascular Science
- Cellular Biology
- Molecular Medicine
Background:
- Autophagy is a known protective mechanism against cellular stress, including hypoxia and myocardial ischemia.
- Its role in ischemic preconditioning, a potent cardioprotective intervention, remains unclear.
Purpose of the Study:
- To investigate the involvement of autophagy in mediating cardioprotection induced by different preconditioning protocols.
- To compare autophagy's role in repetitive ischemia versus traditional first or second-window preconditioning.
Main Methods:
- Utilized swine models to examine autophagy.
- Compared preconditioning induced by six repetitive episodes of ischemia (every 12 hours) with classical first or second-window preconditioning.
Main Results:
- Autophagy was identified as a significant mechanism for cardioprotection in models of repetitive coronary stenosis or occlusion.
- Autophagy's contribution to traditional first or second-window preconditioning was found to be less pronounced.
Conclusions:
- Autophagy is crucial for mediating cardioprotection following repetitive ischemic episodes.
- The role of autophagy in traditional ischemic preconditioning protocols is limited compared to repetitive ischemia models.
Related Concept Videos
01:27Autophagy
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
01:18Autophagic Cell Death
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
01:22Cellular Injury V: Apoptosis and Autophagy
Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
01:17Ischemic Heart Disease: Overview
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...