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Updated: Jun 23, 2026

Corneal Donor Tissue Preparation for Endothelial Keratoplasty
Published on: June 12, 2012
Microkeratome complications
Jimmy K Lee1, Esi W Nkyekyer, Roy S Chuck
1Yale Eye Center, New Haven, Connecticut 06510, USA. jimmy.k.lee@yale.edu
Purpose Of Review:
Complications from laser in-situ keratomileusis surgery are extremely rare. However, most of the complications involve construction of the corneal flap, which is fashioned using various mechanical or femtosecond laser microkeratomes. Here, we review and discuss complications of microkeratome flaps.
Recent Findings:
Several large studies of microkeratome laser in-situ keratomileusis cases report a similar set of complications: partial or irregular flaps, buttonholes, and free flaps. Risk factors for these complications include increased age, preoperative hyperopia, and years of contact lens wear. Numerous animal and clinical studies have shown that the femtosecond platform produces flaps with greater stability with more consistent and accurate dimensions than the mechanical microkeratome. However, there is no significant difference in final visual outcome.
Summary:
The aim of this review is to report complications associated with mechanical microkeratomes in the construction of laser in-situ keratomileusis flaps and to see whether there is a significant disadvantage compared with the femtosecond laser.
Insights
Complications during laser in-situ keratomileusis (LASIK) flap creation are rare. While mechanical microkeratomes have associated risks like irregular flaps, femtosecond lasers offer greater flap stability without impacting final visual outcomes.
Area of Science:
- Ophthalmology
- Surgical Technology
- Corneal Surgery
Background:
- Laser in-situ keratomileusis (LASIK) is a common refractive surgery.
- Corneal flap creation is a critical step in LASIK surgery.
- Microkeratomes, both mechanical and femtosecond laser-based, are used for flap creation.
Purpose of the Study:
- To review and discuss complications associated with microkeratome flaps in LASIK surgery.
- To compare the complication profiles of mechanical microkeratomes versus femtosecond lasers for LASIK flap creation.
- To identify risk factors for microkeratome flap complications.
Main Methods:
- Literature review of studies on LASIK microkeratome flaps.
- Analysis of reported complications such as partial/irregular flaps, buttonholes, and free flaps.
- Comparison of flap characteristics and stability between mechanical and femtosecond laser platforms.
Main Results:
- Common complications include partial or irregular flaps, buttonholes, and free flaps.
- Risk factors identified include older age, hyperopia, and prolonged contact lens wear.
- Femtosecond lasers demonstrate superior flap stability and dimensional consistency over mechanical microkeratomes, with no significant difference in final visual acuity.
Conclusions:
- Mechanical microkeratomes are associated with specific flap complications in LASIK.
- Femtosecond laser platforms offer enhanced flap stability and precision compared to mechanical microkeratomes.
- Despite differences in flap characteristics, final visual outcomes are comparable between the two methods.
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