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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Inflammation01:38

Inflammation

Overview
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

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Related Experiment Video

Updated: Jun 23, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Obesity, inflammation, and atherosclerosis.

Viviane Z Rocha1, Peter Libby

  • 1Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Nature Reviews. Cardiology
|April 29, 2009
PubMed
Summary

Atherosclerosis is now understood as an inflammatory condition, not just a lipid issue. Obesity shares inflammatory pathways with atherosclerosis, aiding in diagnosis and prevention.

Area of Science:

  • Cardiovascular Science
  • Inflammation Biology
  • Metabolic Disease Research

Background:

  • Atherogenesis understanding has shifted from a lipid-storage disease to a subacute inflammatory process.
  • Atherosclerosis involves the infiltration and interaction of macrophages and T cells within the vessel wall.
  • Obesity shares pathological mechanisms with the inflammatory processes driving atherosclerosis.

Purpose of the Study:

  • To highlight the evolving understanding of atherogenesis.
  • To emphasize the inflammatory nature of atherosclerosis.
  • To connect the pathophysiology of obesity with that of atherosclerosis.

Main Methods:

  • Review of current scientific literature on atherogenesis and obesity.
  • Comparative analysis of inflammatory mechanisms in both conditions.

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Last Updated: Jun 23, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
10:17

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

  • Synthesis of findings to inform diagnostic and prognostic strategies.

    • Main Results:

    • Atherosclerosis is characterized by inflammatory cell infiltration and interaction.
    • Obesity exhibits similar inflammatory processes relevant to vascular disease.
    • Shared mechanisms offer new avenues for diagnosis, prognosis, and prevention.

    Conclusions:

    • The inflammatory paradigm of atherogenesis is well-established.
    • Obesity and atherosclerosis share critical inflammatory pathways.
    • This integrated understanding drives innovation in managing these conditions.