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Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

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Updated: Jun 23, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

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Published on: December 11, 2016

Systems approach to therapeutics design.

Bert J Lao1, Daniel T Kamei

  • 1Department of Bioengineering, University of California, Los Angeles, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 29, 2009
PubMed
Summary

This study presents a new method for enhancing protein drug therapies by designing new intracellular transport routes. The approach uses cellular trafficking experiments and mathematical modeling to improve drug delivery and efficacy.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Pharmacology

Background:

  • Protein-based therapeutics offer significant therapeutic potential but often face challenges with intracellular delivery and efficacy.
  • Optimizing the intracellular trafficking of protein drugs is crucial for enhancing their therapeutic properties and targeting specific cellular compartments.

Purpose of the Study:

  • To introduce a general methodology for engineering novel intracellular trafficking pathways to improve protein drug properties.
  • To demonstrate the application of this methodology using the transferrin trafficking pathway as a model system.

Main Methods:

  • Development of a general methodology for engineering intracellular trafficking pathways.
  • Utilization of cellular trafficking experiments to analyze and validate engineered pathways.

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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

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Published on: December 11, 2016

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

  • Application of mathematical modeling to understand and predict trafficking dynamics.

    • Main Results:

    • The described methodology provides a framework for designing and implementing engineered protein trafficking pathways.
    • Successful application of the methodology to the transferrin pathway demonstrates its practical utility.
    • The combination of experimental and modeling approaches allows for comprehensive analysis of trafficking modifications.

    Conclusions:

    • Engineering novel intracellular trafficking pathways is a viable strategy for enhancing protein drug efficacy.
    • The presented methodology offers a systematic approach for developing improved protein-based therapeutics.
    • Further research can build upon this framework to design targeted delivery systems for a wide range of protein drugs.