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Alternative splicing of CCN mRNAs .... it has been upon us

Bernard Perbal1

  • 1R&D L'Oréal, Clark, NJ, USA, bperbal@gmail.com.

Journal of Cell Communication and Signaling
|April 29, 2009
PubMed

Insights

Variant CCN proteins, generated through alternative splicing and post-translational processing, expand the diversity of CCN protein functions in normal and pathological conditions.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • CCN proteins are key regulators involved in various biological processes.
  • Truncated CCN variants are produced via post-translational modifications.
  • Previous studies identified truncated forms of CCN2, CCN3, CCN4, and CCN6, and a naturally truncated CCN5.

Purpose of the Study:

  • To highlight the significance of alternative splicing in generating CCN variants.
  • To emphasize the role of both post-translational processing and alternative splicing in CCN protein diversity.
  • To underscore the emerging acceptance of regulatory functions for CCN variants.

Main Methods:

  • Review of existing literature on CCN protein variants.
  • Analysis of reported cases of CCN protein production, including truncated forms and alternative splicing events.
  • Synthesis of evidence supporting the generation of CCN variants through multiple mechanisms.

Main Results:

  • Alternative splicing, exemplified by CCN1 (cyr61) intron retention in breast cancer, is a significant mechanism for generating CCN variants.
  • This adds to the known post-translational processing of full-length CCN proteins.
  • Evidence supports alternative splicing for multiple CCN genes, increasing CCN protein diversity.

Conclusions:

  • Alternative splicing is a crucial mechanism for generating CCN variants, alongside post-translational processing.
  • These mechanisms significantly increase the biological diversity of CCN proteins.
  • Recognizing these pathways is essential for understanding CCN protein functions in health and disease.

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