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Plasma levels of S100A4 in portopulmonary hypertension

Tien Peng1, Roham Zamanian, Michael J Krowka

  • 1Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|April 29, 2009
PubMed

We previously showed that a single nucleotide polymorphism in S100A4 was associated with portopulmonary hypertension (PPHTN) in patients with advanced liver disease. We aimed to determine the association between plasma levels of S100A4 and PPHTN. We performed a case-control study of patients with advanced liver disease. Cases with PPHTN had mean pulmonary artery pressure >25 mmHg, pulmonary vascular resistance >240 dynes s cm(-5) and pulmonary capillary wedge pressure

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