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Updated: Jun 23, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Mixed f-d coordination complexes as dual visible- and near-infrared-emitting probes for targeting DNA
Aline M Nonat1, Susan J Quinn, Thorfinnur Gunnlaugsson
1School of Chemistry, Center for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
Abstract:
A new family of mixed-lanthanide (Yb(III) and Nd(III)) transition-metal (f-d) cyclen-Ru(II)(phen)(3) (phen = 1,10-phenanthroline) complexes were synthesized as dual visible- and near-infrared (NIR)-emitting DNA probes/sensors. Significant changes were seen in both the Ru(II) visible and the Yb(III)-centered NIR emission, which was switched off upon binding to DNA at pH 7.4. In contrast, no changes were seen in the Nd(III) emission of the analogue f-d conjugate.
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