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Dermatological signs in Wilson's disease
Muammer Seyhan1, Teoman Erdem, Mukadder A Selimoğlu
1Department of Dermatology, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Inonu University, Tip Fakultesi, Pediatri AD, Malatya 44280, Turkey. ayseselimoglu@hotmail.com
Summary
Skin and mucosal findings are common in childhood Wilson's disease (WD). A thorough dermatological examination can help diagnose WD, especially in early stages, with xerosis being the most frequent finding.
Area of Science:
- Pediatric Dermatology
- Hepatology
- Genetics
Background:
- Limited data exists on skin and mucosal findings in Wilson's disease (WD).
- Previous research has not detailed the dermatological manifestations in pediatric WD patients.
Purpose of the Study:
- To investigate the prevalence of mucosal and skin findings in childhood Wilson's disease.
- To identify specific dermatological findings associated with WD in children.
Main Methods:
- Examined 37 children (ages 4-17) diagnosed with Wilson's disease.
- Conducted comprehensive examinations of skin, scalp, mucous membranes, and nails.
Main Results:
- 70.3% of patients exhibited at least one dermatological finding.
- Xerosis was the most common diagnosis (45.7%).
- Skin findings were more frequent in newly diagnosed patients (<2 years).
Conclusions:
- Dermatologists should consider Wilson's disease in patients with various skin, mucosal, and nail abnormalities.
- A detailed dermatological examination can be crucial for early WD diagnosis.
- Skin and mucosal findings are significant indicators, particularly in early-stage Wilson's disease.
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