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Dermatological signs in Wilson's disease

Muammer Seyhan1, Teoman Erdem, Mukadder A Selimoğlu

  • 1Department of Dermatology, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Inonu University, Tip Fakultesi, Pediatri AD, Malatya 44280, Turkey. ayseselimoglu@hotmail.com

Pediatrics International : Official Journal of the Japan Pediatric Society
|April 30, 2009
PubMed

Insights

Skin and mucosal findings are common in childhood Wilson's disease (WD). A thorough dermatological examination can help diagnose WD, especially in early stages, with xerosis being the most frequent finding.

Area of Science:

  • Pediatric Dermatology
  • Hepatology
  • Genetics

Background:

  • Limited data exists on skin and mucosal findings in Wilson's disease (WD).
  • Previous research has not detailed the dermatological manifestations in pediatric WD patients.

Purpose of the Study:

  • To investigate the prevalence of mucosal and skin findings in childhood Wilson's disease.
  • To identify specific dermatological findings associated with WD in children.

Main Methods:

  • Examined 37 children (ages 4-17) diagnosed with Wilson's disease.
  • Conducted comprehensive examinations of skin, scalp, mucous membranes, and nails.

Main Results:

  • 70.3% of patients exhibited at least one dermatological finding.
  • Xerosis was the most common diagnosis (45.7%).
  • Skin findings were more frequent in newly diagnosed patients (<2 years).

Conclusions:

  • Dermatologists should consider Wilson's disease in patients with various skin, mucosal, and nail abnormalities.
  • A detailed dermatological examination can be crucial for early WD diagnosis.
  • Skin and mucosal findings are significant indicators, particularly in early-stage Wilson's disease.
Abstract

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