Case report: Successful IVF programme after conservatively treated endometrial cancer

Area of Science:

• Gynecology
• Reproductive Endocrinology
• Oncology

Background:

• Endometrial cancer diagnosis in young, infertile women presents a challenge for fertility preservation.
• Conservative management strategies are being explored for early-stage endometrial cancer to balance oncologic control and reproductive potential.

Observation:

• A case of a patient with stage 1a grade 1 endometrial cancer who underwent conservative treatment.
• Treatment involved hysteroscopic biopsies and oral megestrol acetate for 3 months, leading to remission to simple endometrial hyperplasia.

Findings:

• The patient conceived successfully through in vitro fertilization (IVF) post-treatment.
• A healthy pregnancy resulted in a full-term delivery via Cesarean section, with no evidence of recurrent disease post-delivery.
• Histological evaluation confirmed disease remission, and the patient remained disease-free for 26 months post-delivery.

Implications:

• Conservative management of stage 1a grade 1 endometrial adenocarcinoma is a viable option for fertility preservation in young women.
• Successful pregnancy following conservative treatment highlights the potential for improved reproductive outcomes in select endometrial cancer patients.
• This approach may offer hope for infertile patients diagnosed with early-stage endometrial cancer, enabling them to achieve pregnancy while managing their disease.