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Published on: August 17, 2015
Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior
Marc J Tetel1, Anthony P Auger, Thierry D Charlier
1Neuroscience Program, Wellesley College, 106 Central St., Wellesley, MA 02481, USA. mtetel@wellesley.edu
Abstract:
Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the steroid/nuclear receptor superfamily of transcriptional activators. A variety of studies in cell lines reveal that nuclear receptor coregulators are critical in modulating steroid receptor-dependent transcription. Thus, in addition to the availability of the hormone and the expression of its receptor, nuclear receptor coregulators are essential for efficient steroid-dependent transactivation of genes. This review will highlight the importance of nuclear receptor coregulators in modulating steroid-dependent gene expression in brain and the regulation of behavior.
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