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Neuroprotective effects of estrogens following ischemic stroke

Shotaro Suzuki1, Candice M Brown, Phyllis M Wise

  • 1Departments of Physiology and Biophysics, and Biology, University of Washington, Seattle, WA 98195-1237, USA.

Frontiers in Neuroendocrinology
|April 30, 2009
PubMed

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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