Related Experiment Video

Updated: Jun 23, 2026

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway

N Presneau1, A Shalaby, B Idowu

  • 1UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.

British Journal of Cancer
|April 30, 2009
PubMed
Summary

Chordomas are resistant tumors. This study found that 65% of chordomas may respond to mTOR inhibitors and AKT inhibitors, offering new treatment strategies for this rare cancer.

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