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Updated: Jun 23, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Residual symptoms in depression.

C Iglesias¹, Mj Alonso

¹Servicio de Psiquiatría, Hospital Valle del Nalón, Pol. de Riaño s/n. Langreo. 33920, Asturias, Spain. icelso@yahoo.es

Actas Espanolas De Psiquiatria

|April 30, 2009

Summary

Subsyndromal depressive symptoms persist in over 30% of patients responding to antidepressants, increasing relapse risk. Addressing these residual symptoms is crucial for better major depressive disorder remission.

Area of Science:

Neuroscience
Psychiatry
Clinical Psychology

Background:

Subsyndromal depressive symptoms are common in unipolar depression despite treatment response.
Over 30% of patients achieving antidepressant response still exhibit residual symptoms, particularly those with initially severe illness.

Purpose of the Study:

To highlight the prevalence and impact of subsyndromal depressive symptoms post-treatment.
To emphasize the need for improved remission strategies in major depressive disorder (MDD).

Main Methods:

Literature review and synthesis of existing research on residual symptoms in depression.
Analysis of symptom profiles (affective, somatic, cognitive, sleep) in treated patients.

Main Results:

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Residual symptoms, including affective, somatic, cognitive, and sleep disturbances, are prevalent.
These persistent symptoms correlate with increased risk of relapse, chronicity, and functional impairment.
Associated neuroanatomical changes are noted in patients with persistent subsyndromal symptoms.

Conclusions:

Subsyndromal symptoms are a significant clinical issue in major depressive disorder management.
Current remission levels may be insufficient, necessitating novel therapeutic approaches.
Further research into strategies for achieving deeper remission is warranted.