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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
A modified oligostilbenoid, diptoindonesin C, from Shorea pinanga Scheff
Yana M Syah1, Euis H Hakim, Emilio L Ghisalberti
1Department of Chemistry, Institut Teknologi Bandung, Bandung, Indonesia.
Researchers isolated a new compound, diptoindonesin C, from Shorea pinanga tree bark. This new oligostilbenoid showed moderate activity against brine shrimp (Artemia salina).
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacognosy
Background:
- Shorea species are known sources of bioactive stilbenoids.
- Oligostilbenoids possess diverse biological activities.
- Exploring Shorea pinanga for novel chemical entities is warranted.
Purpose of the Study:
- To isolate and characterize compounds from the bark of Shorea pinanga.
- To evaluate the biological activity of the isolated compounds.
Main Methods:
- Phytochemical investigation using chromatographic techniques.
- Structure elucidation of isolated compounds via spectroscopic methods.
- Brine shrimp lethality assay for bioactivity screening.
Main Results:
- Isolation of a new oligostilbenoid, diptoindonesin C.
- Identification of known compounds: gnetin H, hopeaphenol, and scopoletin.
- Diptoindonesin C exhibited moderate brine shrimp lethality.
Conclusions:
- Diptoindonesin C is a novel oligostilbenoid from Shorea pinanga.
- The isolated compounds contribute to the phytochemical knowledge of Shorea species.
- Diptoindonesin C demonstrates preliminary bioactivity.
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