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Published on: January 19, 2019
Low-molecular-weight dendrons for DNA binding and release by reduction-triggered degradation of multivalent
Mauri A Kostiainen1, Henna Rosilo
1Department of Engineering Physics, Helsinki University of Technology, P.O. BOX 2200, 02015 HUT, Espoo, Finland. m.kostiainen@science.ru.nl
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 30, 2009
Abstract:
Losing the grip: The synthesis of multivalent low-molecular-weight dendrons with lysine branching units coupled to disulfide-linked spermine surface groups is described. It is furthermore demonstrated that the dendrons bind DNA with good affinity (see image), but are also able to release the DNA in a reductive environment.
