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Antioxidant diterpenoids from the roots of Salvia barrelieri
Ufuk Kolak1, Ahmed Kabouche, Mehmet Oztürk
1Department of General and Analytical Chemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey. ufukkolak@yahoo.com
Introduction:
The phytochemical and biological studies carried out on Salvia species showed that their extracts and constituents have various biological activities.
Objective:
The aim of this study was the isolation of diterpenoids from the roots of Salvia barrelieri Ettling and the determination of the antioxidant activity.
Methodology:
Chromatographic methods were used for fractionation and isolation, respectively. Structure elucidation was established by spectroscopic methods. Five antioxidant assays were performed.
Results:
Three new abietane diterpenoids barreliol, royleanone 12-methyl ether and 7-epi-salviviridinol, and six known diterpenoids, with a known dammarane triterpenoid, pyxinol were isolated. The absolute stereochemistry of pyxinol was confirmed by X-ray analysis.
Conclusion:
Taxodione exhibited the highest antioxidant activity among the tested compounds.
