Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ofloxacin.

A R Tunkel1, W M Scheld

  • 1Department of Internal Medicine (Infectious Diseases), Medical College of Pennsylvania, Philadelphia 19129.

Infection Control and Hospital Epidemiology
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Ofloxacin, a new fluoroquinolone antibiotic, shows efficacy in treating various infections, including gonorrhea. While generally safe, it is not recommended for children or pregnant women.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2013
Same author

Societal costs versus savings from wild-card patent extension legislation to spur critically needed antibiotic development.

Infection·2007
Same author

A pseudo-outbreak of nosocomial infections associated with the introduction of an antibiotic management programme.

The Journal of hospital infection·2003
Same author

Antibiotics for severe chronic obstructive pulmonary disease.

Lancet (London, England)·2002
Same author

Rigid nasal endoscopy versus sinus puncture and aspiration for microbiologic documentation of acute bacterial maxillary sinusitis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001
Same author

Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.

British journal of pharmacology·2001
Same journal

Integrating patient in-hospital transfer patterns into automated outbreak detection systems: a single-center retrospective study.

Infection control and hospital epidemiology·2026
Same journal

Colonization with multidrug-resistant organisms (MDROs) including <i>Candidozyma auris</i> among residents in ventilator-designated versus non-ventilator-designated beds at skilled nursing facilities (SNFs).

Infection control and hospital epidemiology·2026
Same journal

Exploring unconventional antimicrobial stewardship models: options beyond traditional prospective audit and feedback.

Infection control and hospital epidemiology·2026
Same journal

Rectal versus groin screening for multidrug-resistant organisms: pathogen-specific diagnostic yield in a tertiary-care hospital.

Infection control and hospital epidemiology·2026
Same journal

Comparing rapid molecular and culture methods for detecting fungal contamination in healthcare environments.

Infection control and hospital epidemiology·2026
Same journal

Prospective validation and implementation of a model to identify patients with carbapenem-resistant Enterobacterales (CRE) carriage on admission to acute care hospitals.

Infection control and hospital epidemiology·2026
See all related articles

Area of Science:

  • Pharmacology
  • Infectious Diseases

Background:

  • Ofloxacin is a fluoroquinolone antibiotic with a spectrum of activity comparable to ciprofloxacin.
  • It exhibits favorable pharmacokinetic properties, including high oral bioavailability.

Purpose of the Study:

  • To evaluate the antimicrobial spectrum, pharmacokinetics, clinical efficacy, and safety of ofloxacin.
  • To compare ofloxacin with ciprofloxacin for various infections.

Main Methods:

  • Antimicrobial susceptibility testing (MIC90 values) was performed.
  • Pharmacokinetic parameters including bioavailability and peak serum concentrations were assessed.
  • Clinical efficacy was evaluated in treating urinary tract, respiratory tract, prostatitis, and skin infections.

Main Results:

Related Experiment Videos

  • Ofloxacin demonstrated lower MIC90 values than ciprofloxacin for S aureus, C trachomatis, and Ureaplasma urealyticum.
  • It has nearly 100% bioavailability with higher peak serum concentrations than ciprofloxacin.
  • Ofloxacin showed efficacy in treating various infections but is not recommended alone for anaerobic infections.

Conclusions:

  • Ofloxacin is effective for uncomplicated gonorrhea and nongonococcal urethritis.
  • It possesses a good safety profile but should be avoided in pediatric and pregnant populations.
  • Further comparative trials are needed to define its role in treating a broader range of infections.