Flexible polymerosomes--an alternative vehicle for topical delivery
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Updated: Jun 23, 2026

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
Published on: August 11, 2018
Rachna Rastogi1, Sneh Anand, Veena Koul
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India.
Abstract:
Self-assembled vesicles of poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone) co-polymer of 122+/-20 nm were prepared by solvent evaporation method and analyzed morphologically by TEM and AFM. Transmission electron micrographs showed the presence of double-walled deformable structures with average wall thickness of 25 nm. AFM depicted somewhat flattened tops resembling a 'pancake' further confirming the flexibility of the nanocarriers. Permeation studies of fluorescently labelled vesicles in cadaver epidermis confirmed their presence across the stratum corneum within 2h of application and accumulation in the deeper layers thereafter. The flexible nature of these nanosystems makes them an efficient alternative to liposomes for targeting melanomas and basal cell carcinomas.
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