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[Relationship between cystatin C and cerebral infarction]

De-qiang Zhao1, Su-yue Pan, Jian-hui Chen

  • 1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|May 1, 2009
PubMed

Insights

Lower serum cystatin C levels are associated with cerebral infarction. This suggests cystatin C may play a protective role against stroke development.

Area of Science:

  • Biochemistry
  • Neurology

Context:

  • Cerebral infarction, a leading cause of disability, necessitates understanding of protective biomarkers.
  • Cystatin C, a cysteine protease inhibitor, has emerging roles in various physiological processes.

Purpose:

  • To investigate the association between serum cystatin C levels and cerebral infarction.
  • To elucidate the potential protective function of cystatin C in cerebral infarction.

Summary:

  • This study compared serum cystatin C levels in 83 cerebral infarction patients and 71 controls.
  • Serum cystatin C was significantly lower in the cerebral infarction group (1.62±0.31 mg/L) compared to controls (2.23±0.22 mg/L, P<0.01).

Impact:

  • Findings indicate a strong correlation between reduced cystatin C and cerebral infarction.
  • Cystatin C may serve as a potential protective factor against the occurrence of cerebral infarction.
Abstract

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