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Related Concept Videos

Introduction to Connective Tissues01:11

Introduction to Connective Tissues

Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts, osteocytes,...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Classification of Connective Tissues01:30

Classification of Connective Tissues

The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense.
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Loose Connective Tissue01:26

Loose Connective Tissue

Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
Dense Connective Tissue01:13

Dense Connective Tissue

Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...

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Mixed connective tissue disease associated with autoimmune hepatitis and pulmonary fibrosis.

The Israel Medical Association journal : IMAJ·2015
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Cytokine Milieu in Undifferentiated Connective Tissue Disease: a Comprehensive Review.

Clinical reviews in allergy & immunology·2014
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Impaired endothelial function in patients with undifferentiated connective tissue disease: a follow-up study.

Rheumatology (Oxford, England)·2014
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Increased levels of anti-heat-shock protein 60 (anti-Hsp60) indicate endothelial dysfunction, atherosclerosis and cardiovascular diseases in patients with mixed connective tissue disease.

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Autologous dendritic cell based adoptive immunotherapy of patients with colorectal cancer-A phase I-II study.

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Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders.

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Related Experiment Video

Updated: Jun 23, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

[Undifferentiated connective tissue disease].

Edit Bodolay1, Gyula Szegedi

  • 1Debreceni Egyetem, Orvos- és Egészségtudományi Centrum III. Belgyógyászati Klinika Debrecen Móricz Zs. u. 22. 4032. edit.bodolay@gmail.com

Orvosi Hetilap
|May 1, 2009
PubMed
Summary
This summary is machine-generated.

Non-differentiated collagen disease (NDC), or undifferentiated connective tissue disease (UCTD), is an early autoimmune disease stage. Recognizing NDC

Related Experiment Videos

Last Updated: Jun 23, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Rheumatology
  • Immunopathology
  • Autoimmune Diseases

Context:

  • Autoimmune diseases often progress slowly.
  • Non-differentiated collagen disease (NDC), also known as undifferentiated connective tissue disease (UCTD), presents with symptoms and serological markers suggestive of autoimmune conditions but does not meet criteria for established connective tissue diseases (CTDs).
  • Established CTDs include systemic lupus erythematosus (SLE), Sjögren's syndrome, mixed connective tissue disease (MCTD), systemic sclerosis (SSc), polymyositis/dermatomyositis (PM/DM), and rheumatoid arthritis (RA).

Purpose:

  • To define NDC/UCTD as a distinct clinical and serological stage in the evolution of immunopathological diseases.
  • To highlight the dynamic nature of NDC/UCTD and its potential to progress to well-defined systemic autoimmune diseases.
  • To emphasize the importance of recognizing immunoregulatory abnormalities and endothelial dysfunction in patients with NDC/UCTD.

Summary:

  • Approximately 30-40% of patients with NDC/UCTD develop a defined systemic autoimmune disease within five years.
  • The remaining 60% of patients remain in the undifferentiated stage.
  • Immunoregulatory abnormalities and endothelial dysfunction are characteristic findings in the NDC/UCTD stage.

Impact:

  • Early recognition of NDC/UCTD can facilitate timely intervention and management strategies.
  • Understanding the progression of NDC/UCTD aids in predicting patient outcomes and tailoring treatment plans.
  • This research underscores the significance of monitoring patients with undifferentiated profiles for potential development of specific CTDs.