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Related Experiment Videos

Radioiodine therapy in thyrotoxicosis.

M A Taher1, M K Loken, J P Bantle

  • 1Institute of Nuclear Medicine, Dhaka, Bangladesh.

Journal of the Indian Medical Association
|April 1, 1991
PubMed
Summary

Radioiodine (I-131) therapy for thyrotoxicosis effectively induced hypothyroidism in 90% of patients. The study found that the incidence of hypothyroidism was largely independent of the administered radioiodine dose.

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Area of Science:

  • Endocrinology
  • Nuclear Medicine

Background:

  • Thyrotoxicosis, a condition of excess thyroid hormones, requires effective treatment.
  • Radioiodine (I-131) therapy is a common treatment modality for hyperthyroidism.

Purpose of the Study:

  • To evaluate the long-term outcomes of radioiodine (I-131) therapy in patients with thyrotoxicosis.
  • To determine the incidence of hypothyroidism following I-131 treatment and its relationship to administered dosage.

Main Methods:

  • Retrospective analysis of 102 patients treated with I-131 for thyrotoxicosis between 1976 and 1986.
  • Dosages ranged from 3.9 to 100 mCi, with some patients requiring multiple doses.
  • Follow-up data assessed clinical criteria for hypothyroidism.

Main Results:

  • 90% (66 out of 73) of patients with available follow-up data developed hypothyroidism.
  • A small percentage of patients required repeat or triple doses of I-131.
  • The incidence of hypothyroidism appeared independent of the calculated dose (microCi/g thyroid).

Conclusions:

  • Radioiodine (I-131) therapy is a highly effective treatment for inducing hypothyroidism in patients with thyrotoxicosis.
  • Treatment success, in terms of inducing hypothyroidism, is not significantly influenced by the specific radioiodine dosage administered.

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