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Radioiodine therapy in thyrotoxicosis
M A Taher1, M K Loken, J P Bantle
1Institute of Nuclear Medicine, Dhaka, Bangladesh.
Journal of the Indian Medical Association
|April 1, 1991
Summary
Radioiodine (I-131) therapy for thyrotoxicosis effectively induced hypothyroidism in 90% of patients. The study found that the incidence of hypothyroidism was largely independent of the administered radioiodine dose.
Area of Science:
- Endocrinology
- Nuclear Medicine
Background:
- Thyrotoxicosis, a condition of excess thyroid hormones, requires effective treatment.
- Radioiodine (I-131) therapy is a common treatment modality for hyperthyroidism.
Purpose of the Study:
- To evaluate the long-term outcomes of radioiodine (I-131) therapy in patients with thyrotoxicosis.
- To determine the incidence of hypothyroidism following I-131 treatment and its relationship to administered dosage.
Main Methods:
- Retrospective analysis of 102 patients treated with I-131 for thyrotoxicosis between 1976 and 1986.
- Dosages ranged from 3.9 to 100 mCi, with some patients requiring multiple doses.
- Follow-up data assessed clinical criteria for hypothyroidism.
Main Results:
- 90% (66 out of 73) of patients with available follow-up data developed hypothyroidism.
- A small percentage of patients required repeat or triple doses of I-131.
- The incidence of hypothyroidism appeared independent of the calculated dose (microCi/g thyroid).
Conclusions:
- Radioiodine (I-131) therapy is a highly effective treatment for inducing hypothyroidism in patients with thyrotoxicosis.
- Treatment success, in terms of inducing hypothyroidism, is not significantly influenced by the specific radioiodine dosage administered.
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