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Updated: Jun 23, 2026
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Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
[Percutaneous aortic valve replacement in high risk patients]
T Chatterjee1, C A Nienaber, H Schneider
1Abteilung für Kardiologie, Universitätsklinikum Rostock, Rostock.
Praxis
|May 1, 2009
Summary
Degenerative aortic stenosis, a common heart valve disease, affects many adults. Percutaneous aortic valve replacement offers a new durable treatment option for patients unsuitable for traditional surgery.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Interventional Cardiology
Background:
- Degenerative, calcified aortic stenosis is the most prevalent form of adult valvular heart disease.
- Surgical aortic valve replacement is the standard treatment for eligible patients.
- Many patients are excluded from surgery due to advanced age and comorbidities, leading to unmet treatment needs.
Purpose of the Study:
- To highlight the challenges in treating aortic stenosis in elderly and comorbid patients.
- To introduce percutaneous aortic valve replacement as a novel therapeutic option.
Main Methods:
- Review of current treatment guidelines for aortic stenosis.
- Discussion of the evolution of treatment strategies.
- Focus on the advent and implications of percutaneous aortic valve replacement.
Main Results:
- Surgical aortic valve replacement is effective but not feasible for all patients.
- Percutaneous aortic valve replacement provides a viable alternative for high-risk surgical candidates.
- This minimally invasive approach expands treatment accessibility.
Conclusions:
- Percutaneous aortic valve replacement represents a significant advancement in managing aortic stenosis.
- It offers a durable and effective treatment for patients previously denied surgical intervention.
- The development signifies a new era in valvular heart disease therapy.
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