Related Experiment Videos
[Changes of hypothalamo-pituitary-thyroid function after open heart surgery--especially evaluated by TRH test]
1Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai
|August 1, 1991
Summary
Cardiopulmonary bypass surgery significantly suppresses pituitary and thyroid function, potentially indicating euthyroid sick syndrome. The thyrotropin-releasing hormone (TRH) test may gauge surgical stress intensity after bypass.
Area of Science:
- Endocrinology
- Cardiovascular Surgery
Context:
- Open heart surgery impacts endocrine function.
- Cardiopulmonary bypass (ECC) is a significant surgical stressor.
Purpose:
- To investigate pituitary and thyroid function changes post-cardiac surgery.
- To elucidate the mechanisms of these changes using TRH tests and cortisol levels.
Summary:
- Serum concentrations of free T3, free T4, and TSH decreased post-surgery.
- ECC group showed prolonged suppression of TSH and free T4, with suppressed TRH response and elevated cortisol.
- Pituitary-thyroid axis remained suppressed, suggesting euthyroid sick syndrome.
Impact:
- The TRH test can evaluate surgical stress intensity, particularly after cardiopulmonary bypass.
- Findings contribute to understanding endocrine dysfunction following cardiac surgery.