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Related Experiment Video

Updated: Jun 23, 2026

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
07:39

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

Ellipsometric surface plasmon resonance.

Wei-Liang Hsu1, Shu-Sheng Lee, Chih-Kung Lee

  • 1National Taiwan University, Institute of Applied Mechanics, Number 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan.

Journal of Biomedical Optics
|May 2, 2009
PubMed
Summary
This summary is machine-generated.

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We created a novel optical biochip, ellipsometric surface plasmon resonance (ESPR), for detailed biomolecular analysis. This versatile biosensor provides critical data for biotech research and manufacturing applications.

Area of Science:

  • Biotechnology
  • Optical Biosensing
  • Surface Chemistry

Background:

  • Accurate characterization of biomolecular interactions is crucial for biotechnological advancements.
  • Existing biosensing technologies may have limitations in retrieving comprehensive data on molecular monolayers and reaction kinetics.

Purpose of the Study:

  • To develop a multifunctional optical biochip system integrating ellipsometry and surface plasmon resonance (SPR).
  • To introduce the ellipsometric SPR (ESPR) biosensor for detailed analysis of biomolecular properties and interactions.
  • To provide a versatile tool for both research and development and manufacturing in biomedical applications.

Main Methods:

  • Integration of an ellipsometer with a surface plasmon resonance (SPR) system.
  • Development of the novel ellipsometric SPR (ESPR) biochip biosensor.

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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Jun 23, 2026

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
07:39

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

  • Utilizing the ESPR system to retrieve optical properties, surface concentration variations, and kinetic affinity data.

    • Main Results:

    • The ESPR system successfully retrieves detailed information on immobilized biomolecular monolayers.
    • It quantifies surface concentration variations during biomedical reactions.
    • It determines the kinetic affinity between biomolecules, essential for advanced biotech analysis.

    Conclusions:

    • The developed ESPR biochip is a powerful tool for comprehensive biomolecular analysis.
    • Its multifunctional nature makes it suitable for diverse research, development, and manufacturing needs in the biomedical field.
    • ESPR enhances the capability for detailed characterization of biomolecular interactions.