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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Update on diffusion tensor imaging in Alzheimer's disease.

Christopher P Hess1

  • 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, Room L-358, San Francisco, CA 94143-0628, USA. chess@radiology.ucsf.edu

Magnetic Resonance Imaging Clinics of North America
|May 2, 2009
PubMed
Summary
This summary is machine-generated.

Diffusion MRI shows promise for early Alzheimer's disease (AD) detection. This technique may help evaluate mild cognitive impairment and AD, complementing structural MRI by identifying changes earlier in the disease progression.

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Area of Science:

  • Neurology
  • Radiology
  • Biomarker Discovery

Background:

  • Alzheimer's disease (AD) affects over 5 million in the US, necessitating early diagnostic biomarkers.
  • Structural MRI reveals atrophy in late-stage AD, particularly in medial temporal lobes, indicating neuronal loss.
  • Current research explores advanced MRI techniques beyond structural imaging for AD evaluation.

Purpose of the Study:

  • To survey current research on diffusion MRI for mild cognitive impairment (MCI) and AD.
  • To summarize emerging results on diffusion imaging's role in AD assessment.
  • To highlight diffusion MRI as a potential biomarker for early AD diagnosis.

Main Methods:

  • Review of current research on diffusion MR imaging in MCI and AD.
  • Analysis of studies focusing on diffusion imaging techniques and their application.
  • Synthesis of unifying results from diffusion imaging research.

Main Results:

  • Diffusion imaging shows encouraging results in evaluating AD.
  • Emerging evidence suggests a significant role for diffusion MRI in AD assessment.
  • This technique may detect changes earlier than traditional structural MRI.

Conclusions:

  • Diffusion MR imaging is a promising tool for evaluating patients with MCI and AD.
  • Diffusion imaging offers potential as an early diagnostic biomarker for Alzheimer's disease.
  • Further research is consolidating the role of diffusion imaging in clinical practice for AD.