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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jun 23, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Angiogenesis in pre-malignant conditions.

Marius Raica1, Anca Maria Cimpean, Domenico Ribatti

  • 1Department of Histology and Cytology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania. raica@umft.ro

European Journal of Cancer (Oxford, England : 1990)
|May 2, 2009
PubMed
Summary

Angiogenesis, the formation of new blood vessels, is crucial in diseases. This study highlights its role in pre-malignant conditions, suggesting it

Area of Science:

  • Oncology
  • Pathology
  • Vascular Biology

Background:

  • Angiogenesis is vital for normal growth but implicated in disease progression.
  • Tumor-associated angiogenesis is a key focus in oncology with anti-angiogenic therapies.
  • Limited data exists on angiogenesis in pre-malignant conditions.

Purpose of the Study:

  • To investigate the role and evidence of angiogenesis in pre-malignant lesions.
  • To explore the correlation between microvessel density (MVD) and vascular endothelial growth factor (VEGF) in pre-cancerous conditions.
  • To support the evaluation of chemopreventive agents by understanding early angiogenic events.

Main Methods:

  • Evaluation of microvessel density (MVD) in pre-malignant squamous cell lesions.
  • Assessing the correlation between MVD and vascular endothelial growth factor (VEGF) expression.

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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
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  • Immunohistochemical analysis of VEGF expression in pre-malignant glandular epithelia.

    • Main Results:

    • Significantly increased MVD observed in various pre-malignant squamous cell lesions.
    • Correlation found between MVD and VEGF expression in these lesions.
    • Evidence of active angiogenesis, including VEGF expression, in pre-malignant glandular lesions like gastric metaplasia and breast hyperplasia.

    Conclusions:

    • Tumor angiogenesis may be an early event in tumorigenesis, not exclusive to invasive tumors.
    • Active angiogenesis is evident in many pre-malignant conditions.
    • These findings support further research into chemopreventive strategies targeting early angiogenic processes.