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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Quantitative hemodynamic analysis of brain aneurysms at different locations
A Chien1, M A Castro, S Tateshima
1Division of Interventional Neuroradiology, David Geffen School of Medicine, University of California-Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095, USA. aichi@ucla.edu
AJNR. American Journal of Neuroradiology
|May 2, 2009
Summary
Brain aneurysm hemodynamics, including wall shear stress and flow rate, vary by location. Middle cerebral artery aneurysms showed higher values, while basilar and anterior communicating artery aneurysms had lower values.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Computational Fluid Dynamics
Background:
- Cerebral aneurysm occurrence and rupture risk differ by location.
- The underlying reasons for varied clinical presentations of aneurysms at different arterial branches remain unclear.
- Aneurysm hemodynamics are a potential factor influencing growth and rupture.
Purpose of the Study:
- To analyze and compare hemodynamic parameters in cerebral aneurysms situated at distinct arterial locations.
- To investigate the relationship between aneurysm location and blood flow characteristics.
Main Methods:
- Constructed 24 patient-specific aneurysm models using 3D rotational angiographic data.
- Employed computational fluid dynamics (CFD) software for hemodynamic simulations.
- Quantitatively compared wall shear stress (WSS) and flow rate at peak pulsatile flow across different aneurysm locations.
Main Results:
- Significant differences in WSS and flow rate were observed among aneurysms at various locations.
- Middle cerebral artery aneurysms exhibited higher WSS and flow rates.
- Basilar artery and anterior communicating artery aneurysms demonstrated lower WSS and flow rates.
Conclusions:
- Hemodynamic values in cerebral aneurysms are influenced by their anatomical location.
- Further research with larger cohorts is warranted to validate these findings and explore the implications for aneurysm behavior.
