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Updated: Jun 23, 2026
04:30
Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
Does diabetes accelerate progression of calcific aortic stenosis?
Masoor Kamalesh1, Charlotte Ng, Hicham El Masry
1Krannert Institute of Cardiology and Roudebush VA Medical Center, Indiana University, Indianapolis, IN 46202, USA. masoor.kamalesh@med.va.gov
Summary
Diabetes accelerates calcific aortic valve stenosis (CAS) progression in patients with moderate baseline CAS. Statins did not influence CAS advancement in this study.
Area of Science:
- Cardiology
- Endocrinology
- Atherosclerosis Research
Background:
- Calcific aortic valve stenosis (CAS) is an active cardiovascular disease.
- The impact of diabetes mellitus on CAS progression remains incompletely understood.
Purpose of the Study:
- To investigate the effect of diabetes on the progression of CAS severity.
- To compare CAS progression rates between diabetic and non-diabetic patients.
Main Methods:
- Retrospective analysis of 166 patients with CAS and serial echocardiograms.
- Aortic valve area (AVA) measured via continuity equation to assess CAS severity.
- Comparison of demographic and clinical factors, and AVA change over time between diabetic and non-diabetic groups using statistical tests (chi-squared, ANOVA).
Main Results:
- The cohort comprised 166 males (mean age 70 years), with 43% having diabetes.
- Diabetes significantly accelerated AVA decline (a marker of CAS progression) in patients with moderate baseline CAS.
- No significant difference in progression was observed for mild or severe baseline CAS, and statin use did not impact progression rates.
Conclusions:
- Diabetes mellitus is associated with faster progression of calcific aortic valve stenosis in patients with moderate baseline disease.
- Statin therapy does not appear to modify the progression of CAS.
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