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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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GeNMR: a web server for rapid NMR-based protein structure determination.

Mark Berjanskii1, Peter Tang, Jack Liang

  • 1Department of Computing Science, University of Alberta and National Research Council, National Institute for Nanotechnology, Edmonton, AB, Canada T6G 2E8.

Nucleic Acids Research
|May 2, 2009
PubMed
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GeNMR is a web server that rapidly generates accurate 3D protein structures using Nuclear Magnetic Resonance (NMR) data. This tool simplifies protein structure determination, providing high-quality models quickly and efficiently.

Area of Science:

  • Structural Biology
  • Biophysics
  • Computational Biology

Background:

  • Determining 3D protein structures is crucial for understanding biological function.
  • Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique for structure determination.
  • Existing NMR structure determination methods can be complex and time-consuming.

Purpose of the Study:

  • To develop a user-friendly web server for rapid and accurate protein structure generation using NMR data.
  • To streamline the process of protein structure determination for researchers.

Main Methods:

  • GeNMR integrates multiple computational tools including genetic algorithms, homology modeling, and chemical shift threading.
  • It accepts Nuclear Overhauser Effect (NOE)-based distance restraints and NMR chemical shifts as input.

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Last Updated: Jun 23, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering
07:19

Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering

Published on: November 5, 2018

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale
08:09

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale

Published on: April 19, 2021

  • The server utilizes ROSETTA for structure generation and XPLOR-NIH for simulated annealing and refinement.

    • Main Results:

    • GeNMR generates an ensemble of PDB coordinates for proteins within 15-25 minutes.
    • Tests on 90 proteins from the BioMagResBank demonstrated high-quality model generation.
    • The server successfully produced accurate protein models irrespective of the NMR input data type.

    Conclusions:

    • GeNMR significantly simplifies protein structure determination from NMR data.
    • It provides a rapid, accurate, and user-friendly solution for researchers.
    • The web server facilitates wider accessibility to protein structure analysis.