Related Experiment Video
Updated: Jun 23, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Bipolar disorder: emotional dysregulation and neuronal vulnerability
Dan J Stein1, Neil Horn, R Ramesar
1Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa.
Abstract:
Bipolar disorder is clinically characterized by fluctuating affect, and neuropsychologically by impairment in executive functions. Such phenomena are consistent with the centrality of emotional dysregulation and impulsivity to bipolar disorder. They are also consistent with a key role for prefrontal-subcortical (striatal-thalamic) and associated limbic circuitry in its mediation. Furthermore, there is growing data on the cellular mechanisms contributing to neuronal vulnerability in this mediating circuitry.
Related Concept Videos
Bipolar Disorder
Borderline Personality Disorder
Genetic and Environmental Contributions
Borderline Personality...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Bulimia Nervosa
Depression: Overview
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.