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Effect of composite salvia injection on platelet parameters in children with anaphylactoid purpura
Xue-lan Xie1, Su-ru Kou, Yue-hong Xu
1Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, China. hbxxlhbxxl@163.com
Insights
Composite Salvia Injection (CSI) improves platelet function in children with anaphylactoid purpura (AP). CSI treatment normalized abnormal platelet parameters like MPV, PDW, and PCT, indicating functional improvements beyond mere count.
Area of Science:
- Pediatrics
- Hematology
- Immunology
Background:
- Anaphylactoid purpura (AP) involves significant platelet parameter abnormalities.
- Platelet count (BPC) may remain normal, but functional parameters like mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) show deviations.
Purpose of the Study:
- To investigate the efficacy of Composite Salvia Injection (CSI) in modulating platelet parameters in pediatric patients with AP.
- To assess the clinical significance of CSI's effects on platelet function during the acute and convalescent stages of AP.
Main Methods:
- A cohort of 150 children diagnosed with AP was divided into two groups.
- Group A received conventional therapy, while Group B received conventional therapy plus CSI.
- Platelet parameters (BPC, MPV, PDW, PCT) were measured during acute and convalescent phases.
Main Results:
- During the acute phase, AP patients exhibited abnormal MPV, PDW, and PCT levels, despite normal BPC.
- Significant differences in MPV, PDW, and PCT were observed between the CSI-treated group and the control group during the convalescent stage (P<0.05 or P<0.01).
Conclusions:
- AP pathogenesis is associated with functional platelet alterations rather than quantitative changes.
- Composite Salvia Injection (CSI) demonstrates a therapeutic effect by promoting the normalization of platelet function in children with AP.
Objective:
To explore the effect of composite salvia injection (CSI) on platelet parameters in children with anaphylactoid purpura (AP) and its clinical significance.
Methods:
One hundred and fifty children with AP were assigned to two groups, 80 in Group A and 70 in Group B. They were treated, respectively, with conventional therapy only or conventional therapy combined with CSI. Their platelet parameters, including blood platelet count (BPC), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) were determined at the acute stage and convalescent stage, respectively.
Results:
At the acute stage, the BPC in AP children of both groups was in the normal range, but significant abnormality was shown in the levels of MPV, PDW and PCT. As for comparisons of these parameters at the convalescent stage, significant difference between the two groups was also shown in terms of MPV, PDW and PCT (P<0.05 or P<0.01).
Conclusion:
Although platelet shows no quantitative change in the pathogenic process of AP, important functional changes are surely existent. CSI could promote the normalization of platelet function.
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