Related Experiment Video
Updated: Jun 23, 2026

07:57
An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
Published on: December 5, 2025
Analysis of free flap viability based on recipient vein selection
David O Francis1, Ryan E Stern, Daniel Zeitler
1Department of Otolaryngology-Head & Neck Surgery, University of Washington, Seattle, Washington, USA.
Head & Neck
|May 2, 2009
Summary
The configuration of venous anastomosis does not impact microvascular free flap survival. Both end-to-end and end-to-side techniques offer similar flap survival rates, aiding reconstructive surgeons.
Area of Science:
- Plastic Surgery
- Microsurgery
- Head and Neck Reconstruction
Background:
- Venous anastomotic failure is a leading cause of microvascular free tissue transfer failure.
- Two common venous anastomosis configurations exist: end-to-end and end-to-side.
- Optimal venous anastomosis configuration for flap survival remains debated.
Purpose of the Study:
- To evaluate the impact of venous anastomosis configuration on microvascular free flap survival rates.
- To compare flap survival between end-to-end and end-to-side venous anastomoses.
Main Methods:
- Retrospective analysis of 786 microvascular free flaps for head and neck defects (1993-2007).
- Flaps with a single venous anastomosis were stratified into end-to-end and end-to-side groups.
- Bivariate and multivariate analyses compared flap re-exploration and failure rates.
Main Results:
- 87% of flaps utilized an end-to-end anastomosis, while 13% used an end-to-side configuration.
- Overall flap re-exploration rate was 4.3%, and flap failure rate was 1.1%.
- Multivariate analysis showed no significant difference in flap re-exploration or failure rates between end-to-end and end-to-side venous anastomoses.
Conclusions:
- Venous anastomosis configuration (end-to-end vs. end-to-side) does not influence microvascular free flap survival.
- Reconstructive surgeons should be proficient in both techniques to maximize flap success.
- This study supports flexibility in choosing venous anastomosis methods based on surgical context.

