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Related Concept Videos

Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

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Related Experiment Video

Updated: Jun 23, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Acute phase proteins in psoriasis.

Darko Biljan1, Mirna Situm, Kresimir Kostović

  • 1Department of Dermatovenerology, University Hospital "Osijek", Osijek, Croatia. Darko.Biljan@os.t-com.hr

Collegium Antropologicum
|May 5, 2009
PubMed
Summary

Psoriasis patients show elevated levels of acute phase proteins like C-reactive protein (CRP) and alpha1-acid glycoprotein (alpha1-AGP) during acute flare-ups. These markers indicate increased inflammation and may predict disease worsening.

Related Experiment Videos

Last Updated: Jun 23, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Immunology
  • Dermatology
  • Clinical Biochemistry

Background:

  • Psoriasis is a chronic inflammatory skin condition characterized by hyperproliferation.
  • Acute phase proteins (APPs) are implicated in inflammatory responses, with potential roles in psoriasis exacerbations.

Purpose of the Study:

  • To evaluate the inflammatory response during psoriasis exacerbations.
  • To correlate objective inflammatory markers with clinical disease activity.
  • To analyze demographic and epidemiological features in psoriasis patients.

Main Methods:

  • Analysis of plasma levels of selected acute phase proteins.
  • Comparison between 70 patients with acute psoriasis and 40 healthy controls.
  • Statistical analysis including chi-squared tests to assess significance.

Main Results:

  • Significantly increased plasma levels of C-reactive protein (CRP) in acute psoriasis patients compared to controls (chi2 = 23.61; p < 0.005).
  • Significantly elevated plasma levels of alpha1-acid glycoprotein (alpha1-AGP) in acute psoriasis patients versus controls (chi2 = 7.42; p < 0.01).
  • Demonstrated correlation between objective inflammatory parameters and clinical features of disease activity.

Conclusions:

  • Psoriasis exhibits a significant inflammatory component, with worsening linked to increased inflammatory response.
  • Elevated CRP and alpha1-AGP levels may serve as crucial prognostic factors for psoriasis exacerbations.
  • These findings support the utility of APPs as objective markers for monitoring psoriasis activity.