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Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
Published on: December 31, 2014
[Balb/c 3T3 cell transformation assay and its application to the screening of carcinogens]
1Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China. zhlcdc@sohu.com
Wei Sheng Yan Jiu = Journal of Hygiene Research
|May 5, 2009
Abstract:
A cell transformation assay may be an in vitro assay measuring the phenotypic conversion from normal to malignant characteristics in Balb/c 3T3 cells exposed to test chemicals, and capable of detecting carcinogens. In this article, the progress and improvement of Balb/c 3T3 cells transformation assay, and its applications in the detection of tumor initiator and promoter were reviewed.
