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Updated: Jun 23, 2026

Recording Network Activity in Spinal Nociceptive Circuits Using Microelectrode Arrays
Published on: February 9, 2022
[Recent advances in the structure-activity relationship study of small-molecule sodium channel blockers with
Wen Li1, You Zhou, Hong-Min Liu
1College of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China. liwen@zzu.edu.cn
Abstract:
Pain is one of the common clinical symptom, previous studies have implicated sodium channels as a key constituent in pain signaling. Sodium channel blockers with efficient sodium channel blockade effect play an important role in analgesic treatment. However, most drugs used in clinic have many drawbacks and can not meet the demand of the clinical use. Therefore, for the development of new generation of sodium channel blockers, it is of great significance to find small molecule sodium channel blocking lead compounds with novel chemical scaffolds and new structures, sodium channel blocking activity and structure-activity relationship are discussed in detail, and current problems and trends in future research are also emphasized.
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