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Updated: Jun 23, 2026
06:21
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
[Folate receptor-mediated antitumor drugs]
Jie Zhao1, Sheng-Li Cao, Xiao-Lin Zheng
1Department of Chemistry, Capital Normal University, Beijing 100048, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|May 5, 2009
Summary
Folate receptor targeted drugs offer a new way to fight cancer by specifically targeting tumor cells. This review explores novel folate-drug conjugates for improved cancer therapy.
Area of Science:
- Oncology
- Pharmacology
- Biochemistry
Context:
- Folate receptor (FR) is over-expressed in various human cancers.
- FR is minimally expressed in normal tissues, making it a promising cancer-specific target.
- Traditional chemotherapy lacks selectivity, often damaging healthy tissues.
Purpose:
- To review the drug delivery mechanisms for FR-mediated antitumor drugs.
- To highlight novel folate-drug conjugates and their therapeutic activities.
Summary:
- This review details the targeted delivery of antitumor drugs via folate receptors (FRs).
- It explores innovative folate-drug conjugates designed for enhanced cancer cell targeting.
- The mechanisms and activities of these novel conjugates are discussed.
Impact:
- FR-mediated drug delivery enhances therapeutic selectivity, minimizing damage to normal tissues.
- This approach offers a promising strategy for developing more effective and less toxic cancer treatments.
- The review provides insights into next-generation targeted cancer therapies.
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