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Updated: Jun 23, 2026
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HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin
Published on: July 23, 2016
Spectrophotometric determination of tranexamic acid using vanillin
E M A Rind1, M G H Laghari, A H Memon
1Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan. mahboobalirind@yahoo.com
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|May 5, 2009
Summary
A new spectrophotometric method accurately determines tranexamic acid (TA) using vanillin. This stable method is effective for analyzing TA in pharmaceutical products like capsules, injections, and toothpastes.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Tranexamic acid (TA) is a crucial antifibrinolytic agent.
- Accurate quantification of TA in pharmaceutical formulations is essential for quality control.
Purpose of the Study:
- To develop and validate a novel spectrophotometric method for tranexamic acid determination.
- To assess the applicability of the method for analyzing TA in various pharmaceutical products.
Main Methods:
- Spectrophotometric analysis utilizing derivatization with vanillin (VAN).
- Determination of molar absorptivity and adherence to Beer's Law within a specified concentration range.
- Stability assessment of the color reaction over time.
Main Results:
- Molar absorptivity of TA determined as 25,160 L x mol(-1) x cm(-1) at 354 nm.
- Beer's Law adherence observed between 0.5-2.5 microg x mL(-1).
- The developed method successfully quantified TA in capsules, injections, and toothpastes with low relative standard deviation (0.2%-5.0%).
Conclusions:
- The vanillin derivatization spectrophotometric method provides a reliable and stable approach for tranexamic acid quantification.
- The method is suitable for routine quality control analysis of tranexamic acid in diverse pharmaceutical dosage forms.
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