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Updated: Jan 27, 2026

Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
Published on: June 14, 2024
Persistence of HIV-1 silent infection in seronegative subjects at high risk
M Pezzella1, M A Rosci, M Miceli
1Institute of Infectious Diseases, Policlinico Umberto I, University of Rome, La Sapienza, Italy.
Abstract:
Twenty regular sexual partners of HIV-1 infected subjects, without detectable human immunodeficiency virus (HIV-1) antibody and positive for HIV-1 genome by in situ hybridization (ISH), were selected and studied longitudinally for 6-36 months to estimate the duration of silent infection. During the follow-up period, 10 showed atypical Western Blot (WB) patterns. Two seronegative partners seroconverted. Rapid progress to AIDS was observed in 7 seropositive subjects.
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